美国新冠病毒领先中国2代：XBB爆发式突袭 (而且一直在变异中)

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而从新冠毒株的地域分布看，美国东部两个区的XBB毒株比例已经超过50%，因此XBB取代BQ.1和BQ.1.1毒株已经是不可逆转之势。

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CDC tracking rise of new XBB.1.5 COVID variant, already more than 40% of U.S. cases

The Centers for Disease Control and Prevention said Friday it is tracking a new variant of concern dubbed XBB.1.5. According to new figures published Friday, it estimates XBB.1.5 makes up 40.5% of new infections across the country.

XBB.1.5's ascent is overtaking other Omicron variant cousins BQ.1 and BQ.1.1, which had dominated a wave of infections over the fall. Scientists believe its recent growth could be driven by key mutations on top of what was already one of the more immune evasive strains of Omicron to date.

"We're projecting that it's going to be the dominant variant in the Northeast region of the country and that it's going to increase in all regions of the country," said Dr. Barbara Mahon, director of the CDC's proposed Coronavirus and Other Respiratory Viruses Division, in an interview with CBS News.

Mahon said the agency had not listed XBB.1.5 separately in its earlier projections because the strain had not cleared a minimum threshold in the underlying sequences collected by the agency.

The agency's 40.5% figure is only a projection, Mahon stressed, with a probability interval ranging right now from 22.7% to 61.0%.

XBB.1.5's prevalence is largest in the Northeast, the agency estimates. Most of the earliest cases from XBB.1.5 recorded in global databases through early November were sequenced around New York and Massachusetts.

More than 70% of infections in the regions spanning New Jersey through New England are now from XBB.1.5, the agency is projecting.

An increase in hospitalizations
The ascent of XBB.1.5 comes as COVID-19 hospitalizations have accelerated across the U.S. in recent weeks. The pace of new admissions is now worse than this past summer's peak in several regions, but still lower than at this time last winter.



XBB果然来势凶猛

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COVID variants XBB and XBB.1.5 account for 44.1% of U.S. cases - CDC


Dec 30 (Reuters) - Omicron subvariants XBB and XBB.1.5 are estimated to account for 44.1% of COVID-19 cases in the United States in the week of Dec. 31, up from 25.9% in the previous week, data from the U.S. Centers for Disease Control and Prevention showed on Friday. (Reporting by Raghav Mahobe in Bengaluru; Editing by Devika Syamnath)

XBB  已经够烦， 还来个 XBB 1.5

Mr.Bean

楼主提供的信息是有资料有数据做支撑的, 不像某些反中垃圾, 只会出一张臭嘴无理谩骂。

dalap

Around 13% of Americans are currently living in areas of "high" COVID-19 Community Levels, where the agency currently urges masking. Los Angeles, Miami, and New York City rank among the biggest counties now at these levels.

Mahon said XBB.1.5's mutations could be part of driving the increase where XBB had failed to gain a foothold. But she added that other factors, like the higher risk posed by respiratory viruses during the winter holiday season, could also be playing a factor.

Ungrouping XBB.1.5 from XBB
The XBB.1.5 strain is a spinoff of the XBB variant, itself a "recombinant" blend of two prior Omicron strains, which drove a wave of infections overseas earlier this year.

Earlier this year, the Biden administration had voiced optimism that XBB was unlikely to dominate infections in the country. South Asian nations like Singapore reported that strain appeared to pose a lower risk of hospitalization relative to earlier Omicron variants.

After it was first spotted in the country, XBB had made up a small fraction of U.S. cases for several weeks despite appearing in a growing share of variants from arriving international travelers.

Then over the past month, XBB's prevalence began to swell in the CDC's estimates. These figures are released weekly in "Nowcast" projections based on the sequences that authorities have gathered so far.

Now, the CDC says that increase was driven largely by XBB.1.5. After ungrouping XBB.1.5, the agency estimates all other XBB infections currently make up just 3% of cases nationwide.

Beyond its parent, XBB.1.5 has an additional change called S486P. Chinese scientists have reported the mutation appears to offer a "greatly enhanced" ability to bind to cells, which could be helping drive its spread.

"We've been tracking XBB for weeks as I said, and it was XBB and XBB.1, and they really weren't taking off. They weren't increasing rapidly in proportion," said Mahon.

dalap

XBB  ->  XBB 1.5  -> S486P

dalap

XBB  ->  XBB 1.5  -> S486P

从发现， 到变异 都在美国

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Earlier this year, the Biden administration had voiced optimism that XBB was unlikely to dominate infections in the country. South Asian nations like Singapore reported that strain appeared to pose a lower risk of hospitalization relative to earlier Omicron variants.



小新这次翻船

dalap

看样子老霉一直China China China， 就是想声东击西，让大家对XBB掉以轻心吧

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Data from a team of federally-backed researchers earlier this year found the current batch of updated bivalent boosters appear to offer better "neutralizing activity" Omicron variants, including XBB, when testing antibodies in the blood of people who got the updated booster compared to after only the original vaccines.

"We expect that the bivalent booster will provide protection against XBB.1.5 as it has against other Omicron subvariants. And if people haven't gotten it yet, this is a great time to do it," Mahon said.

However, antibody responses in that study were also worse for XBB compared to the other strains they studied.

"The XBB.1.5 variant would look similar to the XBB we tested in our study. The R346T/I mutation within the spike increases the ability of the virus to evade antibodies more efficiently," Emory University's Mehul Suthar told CBS News in an email.


Pfizer 疫苗对XBB 1.5无效

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dalap

小新不承认最早出现在新加坡。
说：
小新不承认最早出现在新加坡。
说：XBB is a relatively new subvariant that was first discovered on 15 August 2022, with cases detected in Australia, Bangladesh, Denmark, India, Japan, Singapore and the United States

老霉放最后。 明白了。

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While Dr Gilman Siu Kit-hang of the Hong Kong Polytechnic University claimed that it was first discovered in Singapore, Dr. Sebastian Maurer-Stroh of the A*STAR’s Bioinformatics Institute disagrees.

Dr. Maurer-Stroh pointed out that the first occurrences of XBB were documented on GISAID (a viral genomic database) from other countries “a few weeks before the first cases in Singapore”.

Regardless of where new variants / subvariants develop, they are often detected earlier in countries that have good genomic surveillance programs.

呵呵， 这句微妙了

dalap

XBB  -> XBB 1.0  XBB 1.5  -> S486P

原来XBB之后还有个变异   XBB 1.0

dalap

Prevalence by location
Est. XBB.1 prevalence last 60 days

https://outbreak.info/situation- ... =XBB.1&selected

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NOT A "SINGAPORE VARIANT"

SINGAPORE: The Ministry of Health (MOH) on Tuesday (Oct 11) debunked rumours that Singapore is seeing a significant increase in severe COVID-19 cases and deaths due to the XBB strain.

MOH also said that while there has been an increase in local cases driven by XBB, including the post-weekend spike of 11,732 cases on Tuesday, the number of severe cases has remained relatively low.


Responding to CNA's queries about overseas media calling the XBB strain the "Singapore variant" or suggesting that it was first found in Singapore, Dr Sebastian Maurer-Stroh, executive director at A*STAR’s Bioinformatics Institute said that the claim was incorrect.

He explained that the first occurrences of the XBB variant documented on GISAID were already in other countries, a few weeks before the first cases in Singapore.

"The numbers of genomes known for a variant vary greatly between countries simply due to the intensity of the sampling and genomic surveillance strategy," he added.

肚腩向前沖啊

给LZ一个大thumps up

dalap

https://www.thailandmedical.news ... eages-such-as-xbb-1,-xbb-1-1,-xbb1-2,-xbb-2,-xbb-3,-xbb-3-1,-xbb-4-and-xbb-5


xbb 1.2
xbb.2
xbb.3
xbb.4
xbb.5

dalap

新变体XBB引发亚洲疫情，传播力和再感染能力超强，值得关注
2022-10-19

北半球逐渐进入寒冷的深秋和冬季，疫情到底会出现什么样的走向呢？这个问题牵动着很多朋友的心。决定疫情走向的一个重点之一，就是不断出现的新冠病毒新变异体，这些新的变异体目前正在呈现出地域性的差异。

在欧美地区，目前新变体BQ.1家族，正在迅速增长，目前这种变体及其亚变体已经占据了美国总感染人数的11.5%左右，而在一个月前，这个占比数据还不到1%。而在亚洲，另一种新变体却呈现出了超强的传播和再次感染能力，这就是新冠病毒的XBB变异体。

XBB变体有多厉害？目前这个变体已经在新加坡成为了绝对的优势毒株，随着这个变异体的迅速传播，目前新加坡目前每天的感染者数量都在1.5万以上，而其中XBB 的感染者比例高达54%以上。根据新加坡卫生部估计，这波浪潮将在11月中旬左右达到顶峰，从目前的数据来看，这个病毒的传染性很强，但并没有引起更严重的疾病浪潮。

这个变体在新加坡引起新一轮的疫情更值得引起关注！新加坡的两针疫苗接种率高达92%，注射加强针的比例也非常高，而本身在多次疫情过程中，新加坡的感染率已经达到了75%，因此不论从疫苗接种率，还是感染率方面，新加坡大多数人对于新冠病毒都是具有抗体的，而在这样的大背景下，这个新变异体能够再次引发新加坡的感染浪潮，说明了XBB变体的超强逃脱免疫能力。统计数据显示，新加坡的二次感染比例正在逐渐上升，在过去的一个月内，二次感染比例已经由原来的5%上升到了17%！

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